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Proceedings Paper

Analysis of conventional swept-source OCT of subglottic stenosis in a rabbit model
Author(s): Ashley Hamamoto; Erica Su; Ya-Sin Peaks; Zhongping Chen; Brian J. F. Wong
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Paper Abstract

Acquired subglottic stenosis is a narrowing of the airway caused by prolonged endotracheal intubation. Currently, there are no non-invasive means to diagnose the disease. A previous study by this same group introduced optical coherence tomography (OCT) as a means of monitoring the progression of stenosis. The aim of the current study was to qualitatively and quantitatively analyze OCT images obtained from a subglottic stenosis model of the rabbit airway. 15 rabbits were used throughout the study, and a MEMs based OCT probe was utilized. The OCT images obtained were analyzed using a free software program, 3D Slicer. The region of scarred tissue was grown out and measured quantitatively. This study demonstrated the feasibility of using a program to quantify the progression of scarring in OCT images, in addition to qualitatively correlating between histology, endoscopic, and OCT images. Future works may include utilization of a long-range probe and use of a pressure necrosis model to better emulate the actual onset of neonatal subglottic stenosis.

Paper Details

Date Published: 8 March 2013
PDF: 6 pages
Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 856521 (8 March 2013); doi: 10.1117/12.2014252
Show Author Affiliations
Ashley Hamamoto, Beckman Laser Institute (United States)
Univ. of California Irvine (United States)
Erica Su, Beckman Laser Institute (United States)
Univ. of California Irvine (United States)
Ya-Sin Peaks, Beckman Laser Institute (United States)
Univ. of California Irvine (United States)
Zhongping Chen, Beckman Laser Institute (United States)
Univ. of California Irvine (United States)
Brian J. F. Wong, Beckman Laser Institute (United States)
Univ. of California Irvine (United States)


Published in SPIE Proceedings Vol. 8565:
Photonic Therapeutics and Diagnostics IX
Andreas Mandelis; Brian Jet-Fei Wong; Anita Mahadevan-Jansen; Henry Hirschberg M.D.; Hyun Wook Kang; Nikiforos Kollias; Melissa J. Suter; Kenton W. Gregory M.D.; Guillermo J. Tearney M.D.; Stephen Lam; Bernard Choi; Steen J. Madsen; Bodo E. Knudsen M.D.; E. Duco Jansen; Justus F. Ilgner M.D.; Haishan Zeng; Matthew Brenner; Laura Marcu, Editor(s)

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