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Proceedings Paper

Measurement of in vivo basal-turn vibrations of the organ of Corti using phase-sensitive Fourier domain optical coherence tomography
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Paper Abstract

A major reason we can perceive faint sounds and communicate in noisy environments is that the outer hair cells of the organ of Corti enhance the sound-evoked motions inside the cochlea. To understand how the organ of Corti works, we have built and tested the phase-sensitive Fourier domain optical coherence tomography (PSFDOCT) system. This system has key advantages over our previous time domain OCT system [1]. The PSFDOCT system has better signal to noise and simultaneously acquires vibration data from all points along the optical-axis [2]. Feasibility of this system to measure in vitro cochlear vibrations in the apex was demonstrated earlier [3]. In this study, we measure the in vivo vibrations of the organ of Corti via round window in live anaesthetized guinea pigs using PSFDOCT. This region of the guinea pig cochlea responds to very high frequencies (10 - 40 kHz). The current vibration noise floor for native organ of Corti tissue is 0.03 nm in this frequency range. Sound-induced vibrations of the stapes, which delivers input to the cochlea, are also measured. The measured vibrations of the organ of Corti demonstrate non-linear compression and active amplification characteristic of sensitive mammalian cochlea.

Paper Details

Date Published: 8 March 2013
PDF: 5 pages
Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 85651V (8 March 2013); doi: 10.1117/12.2009260
Show Author Affiliations
Sripriya Ramamoorthy, Oregon Health and Science Univ. (United States)
Yuan Zhang, Oregon Health and Science Univ. (United States)
Tracy Petrie, Oregon Health and Science Univ. (United States)
Fangyi Chen, Oregon Health and Science Univ. (United States)
Hrebesh Molly Subhash, National Univ. of Ireland Galway (Ireland)
Niloy Choudhury, Michigan Technological Univ. (United States)
Ruikang Wang, Univ. of Washington (United States)
Steven L. Jacques, Oregon Health and Science Univ. (United States)
Alfred L. Nuttall, Oregon Health and Science Univ. (United States)
Univ. of Michigan (United States)


Published in SPIE Proceedings Vol. 8565:
Photonic Therapeutics and Diagnostics IX
Andreas Mandelis; Brian Jet-Fei Wong; Anita Mahadevan-Jansen; Henry Hirschberg M.D.; Hyun Wook Kang; Nikiforos Kollias; Melissa J. Suter; Kenton W. Gregory M.D.; Guillermo J. Tearney M.D.; Stephen Lam; Bernard Choi; Steen J. Madsen; Bodo E. Knudsen M.D.; E. Duco Jansen; Justus F. Ilgner M.D.; Haishan Zeng; Matthew Brenner; Laura Marcu, Editor(s)

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