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Proceedings Paper

A concise algorithm for detection of vibration from Fourier domain OCT
Author(s): S. L. Jacques; S. Ramamoorthy; T. C. Petrie; A. Nguyen-Huynh M.D.; A. L. Nuttall
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Paper Abstract

Optical interferometry using Fourier domain OCT (FD-OCT) can image structures using vibration as the contrast mechanism. An A-scan measurement of light reflected from a tissue at a position x,y yields an intensity spectrum, I(λ), which is sequentially acquired over a short time period, 88 ms, to yield 1000 spectra at equally spaced time points, I(λ,t), while an audio frequency of sound pressure is imparted to the tissue to induce vibration. Analysis converts I(λ,t) into displacement Δz(z,t) of tissue structures along the z axis. Fourier analysis converts Δz(t) at each z into a vibration spectrum, and the amplitude of vibration at the driving audio frequency is specified. This process is repeated for each x position at a given y, to yield an image of vibration amplitude, A(z,x) [nm]. Hence, vibration amplitude becomes the contrast mechanism. This method is not a new idea, but a derivative of Doppler OCT. This report simply provides a concise algorithm in MATLAB for students wishing to implement vibration measurements using FD-OCT. An example shows the vibration of the ossicles of the middle ear viewed through the intact tympanic membrane.

Paper Details

Date Published: 8 March 2013
PDF: 6 pages
Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 85652B (8 March 2013); doi: 10.1117/12.2008966
Show Author Affiliations
S. L. Jacques, Oregon Health and Science Univ. (United States)
S. Ramamoorthy, Oregon Health and Science Univ. (United States)
T. C. Petrie, Oregon Health and Science Univ. (United States)
A. Nguyen-Huynh M.D., Oregon Health and Science Univ. (United States)
A. L. Nuttall, Oregon Health and Science Univ. (United States)

Published in SPIE Proceedings Vol. 8565:
Photonic Therapeutics and Diagnostics IX
Andreas Mandelis; Brian Jet-Fei Wong; Anita Mahadevan-Jansen; Henry Hirschberg M.D.; Hyun Wook Kang; Nikiforos Kollias; Melissa J. Suter; Kenton W. Gregory M.D.; Guillermo J. Tearney M.D.; Stephen Lam; Bernard Choi; Steen J. Madsen; Bodo E. Knudsen M.D.; E. Duco Jansen; Justus F. Ilgner M.D.; Haishan Zeng; Matthew Brenner; Laura Marcu, Editor(s)

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