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Proceedings Paper

Moving Raman spectroscopy into real-time, online diagnosis and detection of precancer and cancer in vivo in the upper GI during clinical endoscopic examination
Author(s): Zhiwei Huang; Mads Sylvest Bergholt; Wei Zheng; Khek Yu Ho; Khay Guan Yeoh; Ming Teh; Jimmy Bok Yan So; Asim Shabbir
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Paper Abstract

A rapid image-guided Raman endoscopy system integrated with on-line diagnostic scheme is developed for in vivo Raman tissue diagnosis (optical biopsy) in the upper GI during clinical gastrointestinal endoscopy under multimodal wide-field imaging guidance. The real-time Raman endoscopy technique was tested prospectively on new gastric patients (n=4) and could identify dysplasia in vivo with sensitivity of 81.5% (22/27) and specificity of 87.9% (29/33). This study realizes for the first time the novel image-guided Raman endoscopy as a screening tool for real-time, online diagnosis of gastric cancer and precancer in vivo at endoscopy.

Paper Details

Date Published: 19 March 2013
PDF: 6 pages
Proc. SPIE 8577, Optical Biopsy XI, 85770G (19 March 2013); doi: 10.1117/12.2005697
Show Author Affiliations
Zhiwei Huang, National Univ. of Singapore (Singapore)
Mads Sylvest Bergholt, National Univ. of Singapore (Singapore)
Wei Zheng, National Univ. of Singapore (Singapore)
Khek Yu Ho, National Univ. of Singapore (Singapore)
Khay Guan Yeoh, National Univ. of Singapore (Singapore)
Ming Teh, National Univ. of Singapore (Singapore)
Jimmy Bok Yan So, National Univ. of Singapore (Singapore)
Asim Shabbir, National Univ. of Singapore (Singapore)

Published in SPIE Proceedings Vol. 8577:
Optical Biopsy XI
Robert R. Alfano; Stavros G. Demos, Editor(s)

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