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Monitoring of human brain functions in risk decision-making task by diffuse optical tomography using voxel-wise general linear model
Author(s): Zi-Jing Lin; Lin Li; Marry Cazzell; Hanli Liu
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Paper Abstract

Functional near-infrared spectroscopy (fNIRS) is a non-invasive imaging technique which measures the hemodynamic changes that reflect the brain activity. Diffuse optical tomography (DOT), a variant of fNIRS with multi-channel NIRS measurements, has demonstrated capability of three dimensional (3D) reconstructions of hemodynamic changes due to the brain activity. Conventional method of DOT image analysis to define the brain activation is based upon the paired t-test between two different states, such as resting-state versus task-state. However, it has limitation because the selection of activation and post-activation period is relatively subjective. General linear model (GLM) based analysis can overcome this limitation. In this study, we combine the 3D DOT image reconstruction with GLM-based analysis (i.e., voxel-wise GLM analysis) to investigate the brain activity that is associated with the risk-decision making process. Risk decision-making is an important cognitive process and thus is an essential topic in the field of neuroscience. The balloon analogue risk task (BART) is a valid experimental model and has been commonly used in behavioral measures to assess human risk taking action and tendency while facing risks. We have utilized the BART paradigm with a blocked design to investigate brain activations in the prefrontal and frontal cortical areas during decision-making. Voxel-wise GLM analysis was performed on 18human participants (10 males and 8females).In this work, we wish to demonstrate the feasibility of using voxel-wise GLM analysis to image and study cognitive functions in response to risk decision making by DOT. Results have shown significant changes in the dorsal lateral prefrontal cortex (DLPFC) during the active choice mode and a different hemodynamic pattern between genders, which are in good agreements with published literatures in functional magnetic resonance imaging (fMRI) and fNIRS studies.

Paper Details

Date Published: 8 March 2013
PDF: 10 pages
Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 856555 (8 March 2013); doi: 10.1117/12.2005538
Show Author Affiliations
Zi-Jing Lin, The Univ. of Texas at Arlington (United States)
Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Lin Li, The Univ. of Texas at Arlington (United States)
Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Marry Cazzell, The Univ. of Texas at Arlington (United States)
Hanli Liu, The Univ. of Texas at Arlington (United States)
Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)

Published in SPIE Proceedings Vol. 8565:
Photonic Therapeutics and Diagnostics IX
Andreas Mandelis; Brian Jet-Fei Wong; Anita Mahadevan-Jansen; Henry Hirschberg M.D.; Hyun Wook Kang; Nikiforos Kollias; Melissa J. Suter; Kenton W. Gregory M.D.; Guillermo J. Tearney M.D.; Stephen Lam; Bernard Choi; Steen J. Madsen; Bodo E. Knudsen M.D.; E. Duco Jansen; Justus F. Ilgner M.D.; Haishan Zeng; Matthew Brenner; Laura Marcu, Editor(s)

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