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Proceedings Paper

Application of laser speckle contrast image in the evaluation of arthritis animal model
Author(s): Taeyoon Son; Won Hyuk Jang; Jihoon Park; Hyung-Ju Yoon; Jeon Lee; Wan-Uk Kim; Byungjo Jung
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Paper Abstract

Arthritis is a chronic inflammatory disease that induces potentially damaging and commonly disabling. Various imaging modalities have been used for the evaluation of arthritis. This study aimed to investigate the feasibility of laser speckle contrast image (LSCI) in the evaluation of the severity and early stage of arthritis in animal model. Arthritis was induced on mouse foot and evaluated by a trained expert and the LSCI. The arthritis severity was quantitatively evaluated by speckle index (SI) computed from LSCI. In visual inspection by an expert, it was difficult to evaluate the arthritis because there was no noticeable different between control mouse group (CMG) and arthritis mouse group (AMG) in erythema. However, arthritis was easily evaluated by significant SI different between the CMG and AMG. In addition, the LSCI also successfully evaluated the early stage of arthritis, presenting different SI distribution depending on lesion.

Paper Details

Date Published: 8 March 2013
PDF: 7 pages
Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 85650Q (8 March 2013); doi: 10.1117/12.2004013
Show Author Affiliations
Taeyoon Son, Yonsei Univ. (Korea, Republic of)
Won Hyuk Jang, Yonsei Univ. (Korea, Republic of)
Jihoon Park, Yonsei Univ. (Korea, Republic of)
Hyung-Ju Yoon, Catholic Univ. of Korea (Korea, Republic of)
Jeon Lee, Yonsei Univ. (Korea, Republic of)
Wan-Uk Kim, Catholic Univ. of Korea (Korea, Republic of)
Byungjo Jung, Yonsei Univ. (Korea, Republic of)

Published in SPIE Proceedings Vol. 8565:
Photonic Therapeutics and Diagnostics IX
Andreas Mandelis; Brian Jet-Fei Wong; Anita Mahadevan-Jansen; Henry Hirschberg M.D.; Hyun Wook Kang; Nikiforos Kollias; Melissa J. Suter; Kenton W. Gregory M.D.; Guillermo J. Tearney M.D.; Stephen Lam; Bernard Choi; Steen J. Madsen; Bodo E. Knudsen M.D.; E. Duco Jansen; Justus F. Ilgner M.D.; Haishan Zeng; Matthew Brenner; Laura Marcu, Editor(s)

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