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Paper Abstract

Novel protocols were developed and applied in the European project “nEUROPt” to assess and compare the performance of instruments for time-domain optical brain imaging and of related methods of data analysis. The objective of the first protocol, “Basic Instrumental Performance”, was to record relevant basic instrumental characteristics in a direct way. The present paper focuses on the second novel protocol (“nEUROPt” protocol) that was devoted to the assessment of sensitivity, spatial resolution and quantification of absorption changes within inhomogeneous media. It was implemented with liquid phantoms based on Intralipid and ink, with black inclusions and, alternatively, in two-layered geometry. Small black cylinders of various sizes were used to mimic small localized changes of the absorption coefficient. Their position was varied in depth and lateral direction to address contrast and spatial resolution. Two-layered liquid phantoms were used, in particular, to determine depth selectivity, i.e. the ratio of contrasts due to a deep and a superficial absorption change of the same magnitude. We introduce the tests of the “nEUROPt” protocol and present exemplary results obtained with various instruments. The results are related to measurements with both types of phantoms and to the analysis of measured time-resolved reflectance based on time windows and moments. Results are compared for the different instruments or instrumental configurations as well as for the methods of data analysis. The nEUROPt protocol is also applicable to cw or frequency-domain instruments and could be useful for designing performance tests in future standards in diffuse optical imaging.

Paper Details

Date Published: 28 February 2013
PDF: 14 pages
Proc. SPIE 8583, Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue V, 85830L (28 February 2013); doi: 10.1117/12.2002438
Show Author Affiliations
Heidrun Wabnitz, Physikalisch-Technische Bundesanstalt (Germany)
Alexander Jelzow, Physikalisch-Technische Bundesanstalt (Germany)
Mikhail Mazurenka, Physikalisch-Technische Bundesanstalt (Germany)
Oliver Steinkellner, Physikalisch-Technische Bundesanstalt (Germany)
Rainer Macdonald, Physikalisch-Technische Bundesanstalt (Germany)
Antonio Pifferi, Politecnico di Milano (Italy)
Istituto di Fotonica e Nanotecnologie, CNR (Italy)
Alessandro Torricelli, Politecnico di Milano (Italy)
Davide Contini, Politecnico di Milano (Italy)
Lucia M. G. Zucchelli, Politecnico di Milano (Italy)
Lorenzo Spinelli, Istituto di Fotonica e Nanotecnologie, CNR (Italy)
Rinaldo Cubeddu, Politecnico di Milano (Italy)
Istituto di Fotonica e Nanotecnologie, CNR (Italy)
Daniel Milej, Nalecz Institute of Biocybernetics and Biomedical Engineering (Poland)
Norbert Zolek, Nalecz Institute of Biocybernetics and Biomedical Engineering (Poland)
Michal Kacprzak, Nalecz Institute of Biocybernetics and Biomedical Engineering (Poland)
Piotr Sawosz, Nalecz Institute of Biocybernetics and Biomedical Engineering (Poland)
Adam Liebert, Nalecz Institute of Biocybernetics and Biomedical Engineering (Poland)
Salavat Magazov, Univ. College London (United Kingdom)
Jeremy C. Hebden, Univ. College London (United Kingdom)
Fabrizio Martelli, Univ. degli Studi di Firenze (Italy)
Paola Di Ninni, Univ. degli Studi di Firenze (Italy)
Giovanni Zaccanti, Univ. degli Studi di Firenze (Italy)


Published in SPIE Proceedings Vol. 8583:
Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue V
Robert J. Nordstrom, Editor(s)

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