Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XVI

OPTIONAL EXTENDED ABSTRACTS

Submissions to this conference may include the following to improve the chance for acceptance:

• 100-word text abstract (for online program). Include author names and affiliations.
• 250-word text abstract (for abstract digest) Include author names and affiliations.
• Optional 2-page extended abstract (for committee review only). The extended abstract must be submitted as a separate PDF document limited to two pages, including tables and figures. Include author names and affiliations; text; any figures, tables, or images; and sufficient data to permit committee review. All submissions will be reviewed by the Program Committee to determine acceptance. Extended abstracts will be used only for the purpose of review, and will not be published.
  
  

Description of the program:

The objective of this conference is to provide a forum to present and collate significant and exciting studies involving chemically or biologically developed optical molecular probes that can be used in biomedical research. Papers appropriate for this solicitation include, but are not limited to studies performed with imaging agents, bioluminescent enzymes, endogenous contrast agents, optogenetic constructs, activatable probes, receptor-, tissue-, or function-specific probes, nanoparticles, and multimodal molecular probes, monitoring molecular and physiological processes in cell and living organisms, clinical use of imaging agents, instrumentation to visualize probes in biological systems, novel algorithms for image analysis and applications of biomarkers and sensors in medicine and biology. This conference will target state-of-the-art studies to highlight the advances in these areas, in vitro or in vivo, and encompasses a wide variety of applications. To accommodate the multidisciplinary nature of the conference, papers are requested from a variety of subject areas, including the following topics:

Design, synthesis, and development of optical probes, contrast agents

• novel optically active molecules (fluorescent, absorption, Raman, infra-red and environment-sensitive dyes)
• novel chemo probes, polymer-based constructs, micelles, liposomes
• quantum dots, carbon dots, gold nanoparticles, upconverting nanoparticles
• theranostic agents
• companion diagnostics

Development of bioluminescence and fluorescent proteins, molecular reporters, vectors and viruses

• fluorescent proteins and bioluminescent agents
• viral constructs with imaging reporters
• voltage-sensitive and optogenetic probes for neuro studies.
  

In vitro and in vivo applications of contrast agents and molecular probes

• genomics and proteomics, including gene expression biological assays, including immunoassays, cell internalization, receptor binding, LRET, FRET and FISH studies
• physiologic function monitoring, including molecular and cellular events, pH, electrolytes, metabolites, minerals, and membrane potential
• imaging of organoids and 3D cell culture
• in vivo organ function monitoring
• molecular, cellular, and tissue imaging
• site-specific delivery mechanisms and endoscopy methods
• multicolor and multimodality imaging systems and upconversion markers
• real-time monitoring of disease progression or regression
• tandem diagnostic and therapeutic interventions
• molecular ruler design and application
• monitoring treatment response
  

Time-resolved tissue spectroscopy for imaging and medical diagnosis

• fluorescence and phosphorescence lifetime spectroscopy and imaging with endogenous probes and exogenous molecules
• new developments in time-resolved instrument design for imaging of cells and tissues.
  

Multi and Hyperspectral imaging for in vitro and in vivo applications [

• Spectral imaging modalities: Visible, fluorescence, SWIR, Raman, Infra-red
• New developments in spectral imaging instrumentation and applications
  

New algorithms for image analysis and processing

• novel algorithms for spectral imaging
• machine and deep learning algorithms and artificial intelligence for analyzing images with contrast agents
• new high throughput methods for high throughput image processing.

Discovery and validation of biomarkers with optical imaging

• identify new disease biomarkers and validate pathways
• imaging disease biomarkers in
• methods for identify and amplify signals for imaging biomarkers.

Pathway to clinical translation of imaging probes and nanomaterials

• human studies using imaging agents
• clinical systems for human studies
• challenges of human translational studies with contrast agents and optical probes
• regulatory issues related to human studies by optical methods.