The Moscone Center
San Francisco, California, United States
1 - 6 February 2020
Conference 11234
Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis
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Abstract Due:
24 July 2019

Author Notification:
30 September 2019

Manuscript Due Date:
8 January 2020


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The goal of this conference is to present novel state-of-the-art work in non-invasive spectroscopic methods to detect the onset and progression of disease, including pre-malignancy and malignancy, and intra-operatively, and tissue and cells response to external conditions, including therapeutic intervention, unintended injury, and laser energy deposition. The conference will focus on work investigating the differences in single and multiphoton excitation optical signatures of normal and diseased tissues, and on understanding the underlying biochemical and structural changes of tissues and cells responsible for the observed spectroscopic signatures. It is worth noting that this symposium has hosted in recent years a number of contributions on the detection of disease using optical spectroscopy signatures of body fluids such as urine or blood plasma. As the field of metabolomics continues to grow, it is possible that “optical metabolomics” maybe a new frontier in the field of Optical Biopsy.

This conference covers a wide array of well-established optical techniques and novel approaches to diagnose tissues changes, including: in vivo and ex vivo fluorescence spectroscopy, Stokes shift spectroscopy, spectral imaging, Raman spectroscopy, multiphoton and photonic methods to modify the tissue and body fluids properties or functions implemented in vivo or ex-vivo covering the technology development steps from bench-to-bedside. Compact pill smart spectral explorers, multi-spectral imagers, coherence effects, and hyper spectral imaging will be highlighted and covered, in part, by speakers.

Topics include:
  • origin of tissue optical properties
  • optical methods for tissue diagnosis and treatment
  • methods for in vivo assessment of physiological state of tissue
  • excitation, absorption, fluorescence spectroscopy and imaging
  • Raman spectroscopy and imaging
  • Resonance Raman spectroscopy
  • inelastic light scattering spectroscopy and imaging
  • stimulated Raman gain spectroscopy and imaging
  • polarization and diffusive reflectance spectral imaging
  • THz spectroscopy and imaging
  • photoluminescence spectroscopy and imaging
  • multi photon spectroscopy and imaging
  • time resolved spectroscopy and imaging
  • speckle and spatial Fourier frequencies spectroscopy for diagnoses
  • ultraviolet diagnostic methods
  • infrared diagnostic methods
  • nano particle tagging and contrast agents
  • chemo- and molecular targeting agents
  • instrumentation of in vivo optical biopsy
  • in vivo spectroscopy and imaging
  • optical processes at the single cell level
  • endoscopes and micro-endoscopes for optical biopsy
  • novel methods for optical biopsy.
  • optical biopsy mapping with linear excitation methods
  • nonlinear optical biopsy mapping
  • novel coherence methods
  • instrumentation for in-vivo optical biopsy
  • video spectral imaging and mapping of tissue
  • STED nano-scale imaging
  • noninvasive detection and imaging of cancer
  • diabetes noninvasive detection
  • assessment of tissue injury
  • photonic applications in neuro science
  • optical methods for brain diseases, Autism, Alzheimer
  • optical metabolomics
  • supercontinuum for medical and biological applications
  • Stokes shift spectroscopy
  • upper excite states for deeper penetration in tissue and brain
  • NIR optical windows in 700 nm to 2500nm
  • MIR optical window 3 µm to 25 µm
  • coherent and non- contact photo-acoustic imaging
  • tissue modification with light pulses
  • laser tissue welding and real time monitoring
  • dynamics of laser-tissue interactions
  • integration of optical detection and therapy systems
  • high resolution imaging methods for in vivo pathology
  • rapid tissue microstructure imaging with intrinsic or extrinsic mechanisms
  • lipidomics
  • fluorescence lifetime imaging (FLIM)
  • phosphorescence lifetime imaging (PLIM)
  • FLIM of fast metabolic effects
  • NADH / FAD fluorescence
  • Clinical FLIM applications
  • advanced multiphoton imaging
  • in-vivo multiphoton tomography of human skin and others.
  • in-vivo FLIM of the human retina
  • protein interaction
  • time-resolved single-molecule spectroscopy.
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