• Newsroom Home
  • Astronomy
  • Biomedical Optics & Medical Imaging
  • Defense & Security
  • Electronic Imaging & Signal Processing
  • Illumination & Displays
  • Lasers & Sources
  • Micro/Nano Lithography
  • Nanotechnology
  • Optical Design & Engineering
  • Optoelectronics & Communications
  • Remote Sensing
  • Sensing & Measurement
  • Solar & Alternative Energy
  • Sign up for Newsroom E-Alerts
  • Information for:

All Technical Articles - Biomedical Optics & Medical Imaging

All Newsroom Technical Articles, starting with the most recently posted:

Jennifer Douris O’Bryan

The US Trade Representative has announced a process for US companies to request permission to continue importing targeted items on a duty-free basis.


7 September 2018
Marks_SMART bandage

Photonics for a Better World

8 August 2018

Halina Rubinsztein-Dunlop on mammalian-like zebrafish brains, the optical tools in her research kit, and her favorite role model.

31 July 2018
GDPR logo from July18 SPIE Pro

In an effort to be 100% GDPR compliant and transparent about data collection policies, SPIE updated its Privacy Policy.

1 July 2018
SPIE CEO Kent Rochford

SPIE's new CEO Kent Rochford, formerly of NIST, stepped into his new role 1 June. We asked Rochford to discuss his views on SPIE and the world of optics and photonics.

11 June 2018
Quantum Tech_cover of SPIE Pro

Devices using quantum technologies are reaching milestones.

6 April 2018
EU regulations

EU-RoHS task force seeks help from the optics and photonics community.

31 April 2018
SPIE PW orange

An industry panel at SPIE Photonics West 2018 discusses the future of additive manufacturing.

28 March 2018
SPIE Photonics for a Better World logo

Photonics for a Better World.

26 March 2018
SPIE Women in Optics logo

A Women in Optics presentation from SPIE Photonics West 2018.

22 March 2018
SPIE PW orange

An interview from SPIE Photonics West 2018.

21 March 2018

World's oldest dedicated university optics center celebrates a hundred years of optics-related research and education, but notes the need to widen participation.

19 March 2018

New imaging tool for recording changes over time, space, and function

16 March 2018
Ovsianikov_PW presentation

A presentation on 3D printing and bioprinting with multiphoton lithography from SPIE Photonics West 2018.

11 March 2018

From the SPIE Photonics West Show Daily: Quantum technology on exhibit at Moscone Center.

7 March 2018
SPIE PW orange

Since its invention near the turn of the century, the optical frequency comb has heralded a new era in optical frequency measurements.

5 March 2018
SPIE logo

The Photonics West Show Daily spoke with recruiters and students about the optics and photonics job market.

26 February 2018

Can quantitative phase imaging help combat dementia and find a cure for cancer? The technology is set but developers need to increase awareness among biologists, hears Rebecca Pool.

19 February 2018

From precision components in breathtaking timepieces to micro-needles for vein cannulation, breakthrough laser writing from Photonics West exhibitor Femtoprint is reshaping microdevice fabrication.

16 February 2018

SPIE, one of seven international organization members of the International Commission for Optics, has supported the mission of the organization for many years.

14 February 2018
optics key challenge_thumb

A new conference incorporating interactive experience at Photonics West reveals the rapid growth of augmented and virtual realities. Its chair, Bernard Kress of Microsoft's Hololens division, tells Matthew Peach that optics remains the key challenge in developing the ultimate virtual experience.

9 February 2018

SPIE is collaborating with other organizations to host grand challenge events aimed at solving problems in medical imaging.

7 February 2018
SPIE PW orange

R&D highlights from the 2018 session: Presentations from leading researchers in biophotonics.

5 February 2018
SPIE PW orange

A day-long industry conference at SPIE Photonics West highlighted optical technological challenges and successes for VR, MR and AR.

31 January 2018

Taking a path less traveled by women.

29 January 2018
SPIE logo

The 2018 SPIE President shares her career path, education, and other interests with the members of SPIE.

27 January 2018
SPIE logo

Since its inception in 1955, SPIE has focused on providing a conduit for ideas in photonics and optics in a growing and vibrant global marketplace.

26 January 2018

By placing quantum dots on top of graphene, a highly sensitive photodetector is constructed that works simultaneously for visible and IR light.

26 January 2018

Optics plays dominant role in medical imaging market.

22 January 2018

SPIE Classics celebrates 25 years of research and development in optical coherence tomography.

10 January 2018

New medical imaging technologies may accelerate the early detection of cancers.

16 November 2017
SPIE Photonics for a Better World logo

Struggles for opportunity and inclusion are familiar to many women and minorities working to make a career in a STEM.

15 November 2017

This SPIE Tutorial Text excerpt discusses the usefulness and versatlity of fiber Bragg gratings.

10 November 2017

SPIE Classics offers a look at STEM education and outreach programs.

8 November 2017
from article 4125

SPIE Classics celebrates 100 years of optics education and research at top-ranked institution.

20 October 2017
from OP presentation, Rajesh R. Naik, USAF

A keynote address from SPIE Optics + Photonics 2017.

5 October 2017
from OP presentation, M. Mantysalo,  TTY

A presentation from SPIE Optics + Photonics 2017.

29 September 2017
from OP planary _Alon Gorodetsky,  UC, Irvine

The Gorodetsky Lab explores the properties of structural proteins known as reflectins, which play crucial roles in the functionality of cephalopod skin.

27 September 2017
from OP plenary_Deji Akinwande, UT Austin

A plenary talk from SPIE Optics + Photonics 2017.

14 September 2017

Photonics industry leaders at SPIE Remote Sensing and SPIE Security + Defence 2017 paint a vibrant picture of Poland's optics and photonics industry.

14 September 2017
Fluorescence, Raman, and nonlinear optical imaging techniques offer subcellular resolution, rapid real-time 3D image acquisition, and the ability to quantitatively analyze the uptake of drugs into skin.
25 August 2017

SPIE Classics celebrates the 100th anniversary of Nikon.

25 July 2017
Super-resolution dipole orientation mapping provides high spatial resolution and accurate dipole orientation information on rapid timescales, and is particularly suited to biological imaging applications.
10 July 2017
In a two-step procedure, a low level of lysosomal photodamage can markedly increase damage to mitochondrial sites.
19 June 2017
Fluorescent plastic beads introduced into cells act as microlasers, thus enabling the identification of individual cells, including cancer and brain cells, that can be tracked from one generation to the next.
31 May 2017
A multicolor widefield-fluorescence-microendoscopy system enables the detection of multiple disease states within the human lung.
18 May 2017

SPIE Classics celebrates the birth of the laser -- 57 years ago this month.

16 May 2017
A variant of optical coherence elastography offers a promising method of distinguishing between tumor and breast tissue in lumpectomy specimens in an intraoperative time frame.
1 May 2017

Space technologies find their place in healthcare applications. (An SPIE Professional article.)

20 April 2017
Light can be used to fabricate, handle, power, and actuate microrobotics functionalities, such as the loading and unloading of microcargo, showing promise for drug delivery and biological-testing applications.
13 April 2017

Optical technology defends against counterfeit drugs. (An SPIE Professional magazine article.)

7 April 2017
The recent development of Brillouin microscopy enables the longitudinal moduli of cells to be mapped in high 3D spatial resolution, without the need for contact or a labeling agent.
21 March 2017
Surface-enhanced Raman scattering can be used as an alternative approach for evaluating the toxicity of nanoparticles in single living cells, bypassing the complications faced by conventional cytotoxicity assays.
12 March 2017
Complementary kernel matching greatly increases the depth of field for time-resolved 3D ranging and snapshot imaging, and shows promise for applications ranging from biomedical microscopy to machine vision.
7 March 2017
An oligonucleotide sequence conjugated to a fluorophore–quencher pair, and then loaded in polymethyl methacrylate nanoparticles, can be used as a theranostic agent.
24 February 2017
A novel spectroscopic method adds functionality for high-spatial-resolution and high-accuracy detection of lipid-rich plaques.
20 February 2017
Photonics West_thumb

From the SPIE Photonics West Show Daily:The first-ever neurophotonics plenary session at Photonics West featured 10 rapid-fire presentations covering the broad spectrum of current neurophotonics R&D.

16 February 2017
Photonics West_thumb

From the SPIE Photonics West Show Daily: Advances in microscopy dominated the BiOS Hot Topics presentations at Photonics West, detailing advances in new techniques that could dramatically influence molecular research, drug development, and clinical diagnostics.

15 February 2017
A suite of flexible and biocompatible threads, embedded with sensors and electronics, can be sutured/woven into tissue for in situ measurements of physical and chemical biomarkers.
13 February 2017
An innovative full-field optical technique can be used to measure deformation of ocular tissue with nanometric accuracy.
8 February 2017
A prototype endoscopic imaging system, based on flexible terahertz waveguide technology, detects tissue abnormalities in real time and may ultimately enhance in vivo cancer screening.
1 February 2017
High-resolution ex vivo imaging of the brain is achieved with a novel technique that will enable studies of normal brain structure and the effects of neurological disorders.
27 January 2017
The journey of a single molecule can be followed with nanometer spatial precision and microsecond temporal resolution by using interferometric scattering optical microscopy and an ultrahigh-speed camera.
25 January 2017
A novel super-resolution approach involves nonlinear scattering from plasmonic nanostructures, including saturation and all-optical switching.
10 January 2017
Stimulated Raman scattering is used together with a novel, small-alkyne-tagged glucose analogue to visualize glucose uptake activity at the single-cell level.
30 December 2016
Recent advances in laser technology enable a betatron hard x-ray source, with which ultrahigh resolution and fast biomedical imaging may be realized.
26 December 2016
Plasmonic oscillations on graphene and 2D biocompatible nanomaterials are combined to yield ultrasensitive devices suitable for clinical diagnostics and early treatment of disease.
9 December 2016
Diffuse correlation spectroscopy and time-resolved near-IR spectroscopy are used in the BabyLux tool to monitor cerebral oxygenation and hemodynamics.
6 December 2016
Quantitative phase-digital holographic microscopy offers high-throughput label-free detection capabilities for identifying cellular biomarkers of mental disorders.
1 December 2016
In the Active Learning in Optics and Photonics program teachers are taught inquiry-based strategies, and low-cost optics technologies are brought to the classroom.
21 November 2016
An amorphous compound, composed of molecular clusters with high optical nonlinearity, enables the generation of continuous-wave white light with the use of a low-cost IR laser diode as the pump source.
18 November 2016
Transfer printing microstructures onto novel hydrogel interfaces and customised composite electrodes could increase the compatibility and information transfer between body tissue and electronic devices.
15 November 2016
A new and versatile method for integrating light-emitting nanoparticles, without loss of their unique properties, into glass is demonstrated.
8 November 2016
A terahertz laser, combined with an uncooled microbolometer camera, is used in a digital holography method to provide improved resolution of skin profiles.
7 November 2016
Stable spatially and spectrally differentiated laser beams can be delivered to remote locations and may thus enable endoscopic in vivo imaging, with resolution beyond the diffraction limit.
3 November 2016
Metallic magnetoplasmonic nanostructures are used for the transducer layers in novel probes to achieve enhanced sensitivity.
24 October 2016
Small laser spots can have a negative impact on the accuracy and precision of measurements when used in surface-enhanced Raman scattering for quantitative characterization.
14 October 2016

A decade's worth of advances in five years is the goal of the photonics community and partners, working on imaging, diagnostics and data management.

23 September 2016
Fundamental and robust pre-processing of cranial computed tomography exams enables algorithms for automatic analysis and interpretation of diagnostic images in acute stroke.
22 September 2016
Two novel approaches enable imaging of cells over large fields of view, with high spatiotemporal resolution.
16 September 2016
Light–matter interactions are strongly coupled in the liquid cores of novel optofluidic devices that are suitable for integration in compact and highly sensitive optical sensors.
14 September 2016
A profiled laser allows for dynamic Raman imaging of living cell structure and functions, and alkyne tags improve the Raman signal with minimal physiological perturbation.
7 September 2016
A photothermal nanoblade couples a metal-tip-coated, wide-bore micropipette and a pulsed laser to induce a microscopic ‘explosion’ that cuts cell membranes, enabling the delivery of mitochondria.
1 September 2016
A holographic optical trapping technique enables 3D manipulation of cytoskeletal filaments, such as for building complex networks that capture key features of biological cell structures.
26 August 2016
An assay based on silver nanoparticles of different colors provides rapid diagnosis for multiple diseases.
24 August 2016
Deconvolving resting-state brain activity from hemodynamic effects reveals a set of spatially and temporally overlapping networks, providing new insights into brain function in health and disease.
15 August 2016
Preliminary results from a single-trial rapid serial visual representation task demonstrate the potential for enabling generalized human-autonomy sensor fusion across multiple subjects.
13 August 2016
A new system enables multiparametric scans for investigating rodent models of diseases and cross-validation studies of bimodal imaging probes.
12 August 2016
A novel strategy is used to synthesize porous gold-silver alloy nanospheres encased in ultrathin silica shells that can act as highly sensitive single-particle probes.
4 August 2016
High-resolution transmission electron microscopy is combined with a novel preparation method, based on superhydrophobic sample control, to achieve a spatial resolution of down to 1.5Å.
3 August 2016
Accurate mechanical measurement of stiffness in individual breast tumor cells provides information that can assist with disease prognosis.
1 August 2016
A novel annihilating filter-based low-rank Hankel matrix approach can be combined with classical analytic reconstruction techniques for application to several compressed sensing imaging problems.
27 July 2016
Silver nanoparticles are used in two different strategies to achieve high sensitivity to parasites and thus facilitate early malaria diagnosis.
27 July 2016
Fully fiber-integrated femtosecond laser systems covering the visible spectrum could take advanced biomedical imaging techniques from the laboratory to real-world applications.
23 July 2016
A cost-effective, freeform method of manufacturing epidermal electronic systems enables long-term, high-fidelity physiological signal monitoring.
21 July 2016
Phase-sensitive imaging and computational correction of patient-specific optical aberrations enable high-resolution imaging of the human retina to aid diagnosis and treatment of eye diseases.
20 July 2016
High-performance detectors that are compatible with mainstream semiconductor device fabrication deliver high speed, ultra-sensitivity, and good timing resolution.
15 July 2016
Combining tightly focused laser beams with surface-treated microtools enables injection and surface biopsies on individual live cells, with minimal disruption to their normal function.
13 July 2016
Tunable light sources and megapixel detectors can improve mid-IR spectral imaging for large-scale histopathological assessment of biological tissues, enabling rapid medical diagnosis.
5 July 2016
A novel project, known as the Pathology Operating System, is being tested and implemented in Sweden for the digitalization of pathology services.
2 July 2016

A graphene-based electronic patch monitors glucose in sweat noninvasively and provides feedback-controlled drug delivery by using microneedles with a heat-responsive coating.

29 June 2016
A photoactivated technique targets tumor cells and simultaneously triggers the release of inhibitors at ‘ the right time and place’ to block the mechanisms that enable some cancers to escape treatment.
24 June 2016

Wearable devices are rapidly advancing in terms of technology, functionality and size, with more real-time applications. The disruption has already begun in health monitoring.

21 June 2016
Image formation based on computation and aberrated optical design provides a promising approach for volumetric imaging studies of biological dynamics at cellular and sub-cellular resolution.
20 June 2016
A new approach enables glucose detection over a spectral range that offers superior depth penetration in tissue, and thus presents possibilities for non-invasive blood sugar monitoring.
15 June 2016
Near-IR light at wavelengths of 1600–1870nm offers the best transmittance for deep brain imaging.
8 June 2016
A comparison of imaging using deuterium oxide and water immersion media shows that deuterium oxide significantly enhances signals for image contrast in the 1700nm excitation window.
1 June 2016
Finite element technology and practical insights can enhance the accuracy of magnetic resonance-guided ultrasound biopsy of the prostate.
27 May 2016
Lanthanum fluoride particles passively collect in tumors and amplify applied radiation doses, while also transferring energy to photosensitizer dyes that enable the targeting of cancerous cells.
20 May 2016
The integration of a time-variable array of pinholes can be used to perform high-resolution imaging with high energy efficiency, and significantly extend the field of view when combined with an imaging lens.
16 May 2016
A digital holographic microscope operating in telecentric mode could be used to diagnose diabetes and evaluate long-term glycemic control in patients with diabetes.
9 May 2016
A hexagonally patterned hyperlens array enables high-throughput super-resolution imaging of living cells, without the need for complex optical systems.
4 May 2016
Quantum dots exhibit a measurable rapid photoluminescence response to neuron-like electric fields and can thus be used to observe neuronal action potentials.
27 April 2016
The butterfly proboscis is a unique, naturally engineered device for acquiring liquid food, and may inspire novel developments in micro- and nanofluidic engineering.
21 April 2016
Applying optical imaging to cellular mechanisms one cell at a time could improve disease detection and diagnosis.
19 April 2016
Combining stimulated-emission-depletion microscopy with fluorescence-correlation spectroscopy enables the simultaneous confocal and super-resolution monitoring of molecular diffusion.
9 April 2016
A new microfluidics-based 3D tissue culture method facilitates rapid and simultaneous viability measurements on multiple samples, offering the possibility of patient-specific assays.
28 March 2016
A tiny, low-cost evanescent-field biosensor chip with a directly integrated optical detector enables carcinogenic contaminant detection and shows promise for point-of-use application.
21 March 2016
Analyzing the optical properties of plant cells forms the basis for an adaptive optics microscope that obtains near-diffraction-limited images.
9 March 2016
Incorporating adaptive optics, such as a deformable mirror, in super-resolution microscopy enables imaging of structures at depths of 15μm.
2 March 2016
The DNA nucleobase guanine can maintain graphene's electrical properties, and may have potential applications in flexible, graphene-based sensors for use on the body.
18 February 2016
Detecting proteins and nanobioparticles using microarray technologies enables resolution and sensitivity beyond the reach of ensemble measurements.
18 February 2016
A multimodal optical imaging approach enables assessment of the long-term reliability of microelectrodes used to record brain activity, stimulate specific cortical regions, and control neural prostheses.
16 February 2016
A handheld fiber probe with adjustable offsets enables spatially offset Raman spectroscopy at different depths for noninvasive analysis of callus composition during fracture healing.
15 February 2016
DNA electronic devices can distinguish various forms of DNA damage and are now being used to follow anticancer drug activity.
6 February 2016
Integration of planar nanophotonics and microfluidics offers a new route for high-throughput sorting of bacterial cells in real time.
28 January 2016
Long-range surface plasmon polariton waveguides are used in a novel sensor for the detection of kappa and lambda light chain immunoglobulin relative concentrations.
22 January 2016
Non-invasive imaging through scattering media is achieved with the use of patterned illumination and single-pixel photodetection.
18 January 2016
Errors in the detection of phase changes by optical coherence tomography can be reduced significantly by using volumetric recording of images and digital image-processing techniques.
13 January 2016
Bridging the gap between electronics and biology, bioprotonic devices control protonic currents (H+), which may affect physiological function.
11 January 2016
The photorefraction of IR light and astigmatism from a cylindrical lens are used to assess variations in the human eye as a function of perceived depth information.
8 January 2016
Focus shaping using vortex laser beams improves precision in corneal surgery by facilitating cleavage along the lamellae in the cornea, and enables cutting with reduced absorbed pulse energy.
7 January 2016

Advanced algorithms that leverage computer vision and signal processing concepts are used to estimate vital signs from small changes in skin color.

30 December 2015

Quantitative image information combined with personal risk factors can provide breast screening that is better tailored to the individual.

28 December 2015

A technique that distinguishes single from multiple scattered waves achieves microscopic imaging with a near-diffraction-limit resolution of 1.5μm, at depths that would benefit medical applications.

22 December 2015

Microlasers can be embedded inside single mammalian cells, enabling the tagging of a large number of cells and very sensitive real-time sensing of the forces and refractive indices within cells.

21 December 2015
An integrated fluorescence spectroscopy approach can be used to examine the diffusion of molecular probes, protein folding processes, and several biochemical reactions.
11 December 2015
A technique combining Raman and Fourier transform IR spectroscopies enables simultaneous topographical and chemical imaging at high resolution.
4 December 2015
Biomedical imaging for preclinical applications is rapidly advancing and benefiting from the introduction of powerful new computing hardware.
3 December 2015
Imaging techniques based on autofluorescence and reflectance offer objective diagnosis of middle-ear pathological conditions.
30 November 2015
Nanoformulated compound derivatives naphthalocyanines enable dual-color photoacoustic demarking of lymph node networks.
20 November 2015
Multifunctional fibers enable simultaneous recording, optical stimulation, and drug delivery into the nervous system.
16 November 2015
A combination of optics coding and digital processing enhances the capabilities of traditional light microscopes, enabling acquisition of information such as phase, which cannot otherwise be captured.
4 November 2015
Supported membranes typically used in bionanotechnological devices have a higher degree of order than free membranes and show lipid clustering, which could affect device functioning.
3 November 2015
A three-camera microscope without moving parts enables fast and accurate tracking of individual enzyme molecules, their regulators, and catalytic product molecules simultaneously in the nuclei of living cells.
2 November 2015
A monolithic optofluidic chip fabricated by femtosecond laser extracts highly metastatic cells from a heterogeneous population on the basis of optical stretching measurements.
27 October 2015
Electrochemical transistors based on organic polymers enable a potentiometric sensing platform for flexible, versatile, and disposable biosensors.
22 October 2015
Compensating for modal scrambling during illumination and detection enables the use of multimode fibers to transmit high-contrast, confocal images for endoscopic applications.
16 October 2015
A new tactile sensing device that simultaneously detects thermal and mechanical stimuli could find use in artificial skin systems.
14 October 2015
Automatic analysis of x-ray images enables on-site screening for tuberculosis infection, addressing the shortage of trained radiologists in rural Kenya.
8 October 2015
A new USB-powered lightweight device was developed to improve early detection of glaucoma and other eye diseases.
28 September 2015
Combined spatial frequency domain imaging enables improved monitoring of hypertrophic scar formation, making interventional procedures more effective.
24 September 2015
Holographic control of light traveling through multimode optical fibers enables minimally invasive imaging deep inside sensitive living tissues.
23 September 2015
Focused ultrasound combined with sensitizing agents used in photodynamic therapy increases the ability of anti-cancer drugs to inhibit tumor growth.
12 September 2015
Upconverting nanoparticles are coupled with gold nanorods to achieve increased emission brightness, enhanced diagnostic strength, and improved determination of local temperature.
25 August 2015
A holographic optical-tweezers-based approach allows the fabrication of bacterial microsystems, such as fluid mixers or micro- and nanotransport vehicles for functional particles.
20 August 2015
Smart design of optofluidic labs-on-chips offers the sensitivity of laboratory-scale optical detection instruments with portability, fast response times, low sample consumption, and parallel processing and read-out.
12 August 2015
MRI sparse sampling and constrained reconstruction techniques enable high-resolution images of the entire brain with no increase in scan time or apparent loss of diagnostic information.
3 August 2015

Quantitative analysis of contrast-enhanced ultrasound enables fast, 97% accurate diagnosis and assessment of rheumatoid arthritis for personalized therapy.

6 July 2015

Integrating highly efficient energy conversion materials onto stretchable and biocompatible substrates could yield breakthroughs in implantable biomechanical energy harvesting systems.

21 July 2011

Innovative imaging techniques as well as teaching methods have helped advance research at the biophotonics laboratory at Vanderbilt University.

15 June 2011
Smaller, faster, cheaper optical biosensors offer the capacity to provide effective and actionable information.
28 April 2011
Boyden's award-winning research has led to tools that can activate or silence neurons with light, enabling the causal assessment of how specific neurons contribute to normal and pathological brain functions.
21 April 2011

A turkey carcass played a key role in discovering the potential of the argon-fluoride excimer laser at 193 microns and its eventual widespread application in eye surgery.

4 April 2011
Using stimulated emission depletion microscopy and other techniques, Stefan Hell explores new ways to examine living cells noninvasively.
1 April 2011
Mark ReaSolid-state lighting and the discovery of a new photoreceptor in the brain have stimulated the study of how light impacts biological systems.
15 March 2011

Based in Jena, the birthplace of optical technology in Germany, JENOPTIK's Michael Mertin has a unique perspective on the industry's past and future.

28 February 2011
Audio recordings and slides from plenary presentations at SPIE Photonics West 2011.
7 February 2011

Clinical Multiphoton Tomography - Karsten Koenig presentation from BiOS Hot Topics session at SPIE Photonics West 2011

31 January 2011

New Developments in OCT for Ophthalmology - David Huang BiOS Hot Topics presentation at SPIE Photonics West 2011

31 January 2011

Training more high-school physics teachers and increasing student learning are two of the challenges facing math, science, and engineering education in the United States.

17 December 2010
The vice president of engineering at CVI Melles Griot Laser Group talks about the company's evolution and efforts to serve the biomedical instrument market.
19 November 2010
With properties that don't exist in nature, metamaterials open up an exciting range of possibilities.
10 November 2010
The father of the FEL talks about current research and potential applications of the technology, from genetics to defense and security.
19 October 2010
Tissue pathology can be detected in vivo by optical methods through minimally invasive endoscopy. Work at the BC Cancer Agency in Vancouver is focused on Raman spectroscopy of internal and external surfaces.
16 July 2010

In his lab at Oregon Health and Science University, Jacques and his researchers have developed new modalities for diagnosis and treatment. He reflects on the laser's key role.

26 May 2010

Nozomi Nishimura explains how researchers use femtosecond laser pulses to model and study the effects of stroke and Alzheimer's in brain cells.

30 April 2010
Katarina Svanberg laser interviewLasers have a multifaceted role in oncology, and have increased patient survival through their use in tumor detection and treatment.
16 April 2010

The clinical uses of PDT have expanded, and research is underway on a variety of cancers as well as infectious diseases.

19 March 2010

The SPIE 2010 Gold Medal winner reminisces about the formative years of the laser, and talks about new horizons in science.

26 February 2010
The chief technology officer of LightLab Imaging talks about the company's efforts in developing optical coherence tomography products for clinical use.
25 February 2010
The first integrated-circuit vocal tract, combined with a bionic ear processor in a feedback speech-locked loop, provides a new way to process speech.
3 February 2010

Nanoscopy with Focused Light - Stefan Hell plenary presentation from SPIE Photonics West 2011

31 January 2010

Novel Uses of Femtosecond Laser Pulses in Biophotonics - Eric Mazur presentation from the BiOS Hot Topics session at SPIE Photonics West 2011

31 January 2010

In this 10 minute presentation from the BiOS Hot Topics session at Photonics West 2011, Ed Boyden talks about his research at MIT.

31 January 2010
Jim Fujimoto works with students and patients to expand the clinical applications of biomedical optics.
21 January 2010
Leon Esterowitz completed his PhD in the early 60s in the early days of the laser. After a career in defense, he moved to NSF, and now reviews funding proposals in biophotonics.
13 January 2010
Rox Anderson, symposium chair of SPIE Biomedical Optics at Photonics West, talks about the important role of lasers in medicine, from cancer to heart disease and his own specialty, dermatology.
5 January 2010
Integration of biological molecules into nanoelectronic devices promises new, sophisticated biointerfacing technologies.
9 December 2009
A new method for killing viral particles may have important medical applications like disinfecting blood components and treating diseases.
3 December 2009
Automated classification of individual blood-vessel abnormalities may improve the efficiency of a common test for autoimmune diseases.
18 November 2009
Combining a post-acquisition rearrangement procedure with optical coherence tomography can provide high temporal resolution for capturing subtle dynamics in the early avian embryonic heart.
17 November 2009
Spectral-domain optical coherence tomography performed simultaneously in two distinct wavelength bands permits better diagnosis of tumors.
9 November 2009
High-frame-rate, real-time laser Doppler imaging of biological tissue uses advances in optical sensing and processing.
30 October 2009
Using light to inject a single nanosized biosensor into a mammalian cell enables analysis of its biochemistry.
20 October 2009
The combination of microfluidics and plastic electronics could bring laboratory-quality analysis to the practitioner in the field.
16 October 2009
A new technique to remove complex-conjugate artifacts inherent to conventional Fourier-domain interferometry can double accessible imaging depth.
13 October 2009
An electro-optic lens with voltage-controlled focusing power across the aperture takes a new approach to adjusting vision as people age.
6 October 2009
Bioinformatic techniques enable identification of extremophile life forms well adapted to extraterrestrial environments such as Mars.
30 September 2009
A proposed model for migrating birds' magnetic sense can withstand moderate orientational disorder of a key protein in the eye.
23 September 2009
Transduction of molecular recognition by closely packed organic electronics and membrane proteins may enable accurate, label-free diagnostic testing.
23 September 2009
Determining the characteristic quadratic hyperpolarizability of amino acids for single molecules and short peptides enables advances in tissue imaging.
23 September 2009
Optical coherence microscopy has potential as a tool for noninvasively measuring electrical activity in single neurons based on changes in their intrinsic optical properties.
16 September 2009
Combining organic lasers with optical waveguides and microfluidic channels may enable inexpensive, disposable diagnostic tests that can be analyzed at the patient's bedside.
15 September 2009

From fabric that can process images to laser communication to brain surgery, Yoel Fink of MIT describes some of the uses of multimaterial fibers.

9 September 2009
Ancient weathering crusts are often the only source of information about the conditions under which development of our biosphere occurred.
4 September 2009
The former president of MIT spoke at the SPIE Optics + Photonics Symposium Awards Banquet.
13 August 2009
A wavelet method that employs Monte Carlo ray sampling fully accounts for diffraction and interference in complex media.
7 August 2009
Fluorescent probes enable nondestructive, in situ microscale viscosity measurements.
7 August 2009
The fabrication process can reduce multiple scattering effects and decrease pixel size, paving the way for improved x-ray, charged particle, and neutron detectors.
5 August 2009
Photodynamic therapy represents a paradigm shift in oncological medication from traditional resection and systemic chemotherapy methods.
22 July 2009
A large, dynamic-range Shack-Hartmann wavefront sensor allows the characterization of higher-order aberrations in keratoconic and post-corneal transplant eyes.
21 July 2009
Selective electrolysis of phosphate-buffered saline may provide oxygen directly to retinal tissue with minimal coproduction of harmful free chlorine.
15 July 2009
Characterizing how nanoparticles affect organs and accumulate in tissue may provide insight into their safety as a potential cancer therapy
15 July 2009
Polarization-sensitive optical coherence tomography enables tissue-sensitive visualization of the front of the eye.
9 July 2009
Improved understanding of the fundamental cellular and molecular mechanisms is broadening the technique's mainstream use for many ailments.
9 July 2009
A novel approach enables user-defined manufacture of biocompatible and biodegradable polymer structures for regenerative medicine.
6 July 2009
A new system for ultrahigh-speed imaging of the anterior segment of the eye retains micrometer resolution.
6 July 2009
Growing indium nitride film in a different orientation paves the way for noninvasive analysis of chemical composition.
1 July 2009
A new class of photonic-crystal fiber with a hollow core and various lattice modifications may be an important component for biosensing applications.
30 June 2009
A new data-capture method could provide increased flexibility for clinical imaging applications.
30 June 2009
A computerized tool gives radiologists a second opinion for diagnosing breast cancer.
30 June 2009
A new family of chemical labels with much longer lifetimes than traditional fluorophores are key to a new biological imaging method: time-resolved emission imaging microscopy.
24 June 2009
Intensity-based Doppler optical coherence tomography gives an accurate, high-speed, 3D readout of ocular blood flow.
24 June 2009
Sub-Angstrom-resolution sensing of tiny cantilevers is leading the way to a gentle physical probe for surfaces of materials such as living cells.
19 June 2009
Detailed, real-time imaging allows for adjustment of surgical margins, thus sparing healthy tissue and increasing the likelihood of complete tumor removal.
19 June 2009
Pressure waves caused by nanosecond laser pulses can be used to deliver macromolecules to cells and tissues.
16 June 2009
A new technique for monitoring blood flow will help investigate eye functions and retinal disease.
10 June 2009
Top SPIE Newsroom articles from the previous month, and papers from SPIE Journals and Conference Proceedings.
9 June 2009
Monitoring biochemical interactions can serve as the basis for many diagnostic techniques.
5 June 2009
A hybrid magnetic-resonance/fluorescence imaging system aids identification and study of tumors.
1 June 2009
By using optical nanocavity resonators, the interaction between the light and target molecules is enhanced more than a million times, leading to improved single-molecule detection.
26 May 2009
Laser-induced ultrasound can aid the early detection and monitoring of metastatic disease.
22 May 2009
Very detailed 3D scans of a 3000-year-old mummy of an Egyptian temple singer and priestess are made freely available for in-depth follow-up studies.
18 May 2009

Long wavelength light permits in vivo imaging of the human eye at a cellular scale.

18 May 2009
Electronics, sensors, and communication capabilities will all be embedded in future contact lenses, presenting new opportunities in applications ranging from medicine to virtual reality.
15 May 2009
A combination of waveguides and microfluidics is easily achieved through femtosecond-laser micromachining.
14 May 2009
By exploiting the extra information available from 3D imaging in a virtual reality environment, surgeons can individualize the pre-planning of surgery on the kidneys.
13 May 2009
Blindly separating images prior to applying tissue-contrast-enhancing algorithms shows clear improvements over current techniques.
12 May 2009
Innovations in photonics and microfluidics have enabled the development of a novel, rapid, sensitive, low-cost, and portable micro-gas analyzer.
4 May 2009
Recent advances in imaging technology facilitate cellular-resolution retinal imaging and wide-field 3D visualization, enabling enhanced penetration below the retina for routine diagnosis.
3 May 2009
This patent review from Nerac explores some new developments in retinal implants that may speed their acceptance for treating blindness.
1 May 2009
The successful demonstration of near-IR contrast agents brings non-nuclear diagnosis closer to clinical use.
29 April 2009
A combination of polarization and Doppler-flow imaging for optical coherence tomography enhances image contrast without sacrificing acquisition speeds.
24 April 2009
A Web-accessible, content-based system for searching a large cervigram database may play an important role in medical education and cervical-cancer research.
14 April 2009
A device combining optical coherence tomography and adaptive optics can capture micron-scale 3D pictures of the retina.
6 April 2009
Optical coherence tomography enhances clinical diagnosis and could increase our understanding of major disease progression.
25 March 2009
Even after multiple applications of sunscreen, the UV-blocking particles remain localized close to the skin surface and produce insignificant numbers of free radicals.
23 March 2009
Advances in monitoring the response to photodynamic therapy may permit real-time dosage adjustments, improving the outcome for patients.
17 March 2009
Individuals and organizations must work together to reduce pediatric radiation exposure.
13 March 2009

Margaret Wertheim describes her work on the Institute for Figuring.

3 March 2009
Diffusion imaging already offers an unprecedented view of the human brain's structure, but it is still an evolving field, providing opportunities for future technical and scientific developments.
3 March 2009
An advanced imaging technique has both the spatial and temporal resolution to investigate the developing heart in important animal models such as chicks and mice.
24 February 2009
Innovations in microfluidic technologies enable rapid in vivo studies employing two-photon microscopy and femtosecond laser nanosurgery.
24 February 2009
Near-IR fluorescent dye encapsulated in calcium-phosphate nanoparticles maintains enhanced brightness for up to four days in human breast-cancer tumors systemically injected into live mouse models.
9 February 2009
Satellite sensors track sources of desert dust for models that predict particle entrainment and atmospheric pollution, resulting in new tools to support public safety and health services.
9 February 2009
Plasmon coupling facilitates detection of direct contacts between optically colocalized gold nanoparticles in optical wide-field microscopy.
9 February 2009
A new operating regime for rapidly wavelength swept, narrowband light sources has enabled high-performance biomedical imaging.
3 February 2009
A tensor method applied to diffusion images provides better reconstructions of nerve fiber crossing than linear methods.
30 January 2009
See-through fish embryos help to demonstrate the advantages of an integrated approach in testing how small particles can alter living organisms.
23 January 2009
Novel fluorescence lifetime-based instrumentation and methodologies enable the development of near-real time clinical diagnostic devices for heart disease and tumors.
21 January 2009
Optical trapping and manipulation of carbon nanotubes using optical tweezers leads to next-generation photonic force microscopy.
19 January 2009
A water-resistant surface inspired by the lotus leaf could enable applications in microfluidics, underwater coatings, and controlled deposition.
19 January 2009
A sparse image model combined with a novel nonlinear reconstruction algorithm can obtain high-quality imaging with significantly fewer measurements than traditional approaches.
15 January 2009
Advances in optical-coherence tomography may lead to a new class of endoscopic, image-guided therapies that target disease with microscopic precision.
15 January 2009
Optical imaging systems that identify molecular signatures of cancer can address clinical needs in both the developed and the developing world.
15 January 2009
Illuminating bodily tissues with a digital micromirror device enables non-invasive characterization of living tissue based on chemistry and morphology.
31 December 2008
Combining semiconductor technology with photonics, optics, and biochemistry leads to sensors with improved biomedical diagnostic capability.
31 December 2008
An innovative single optical fiber configuration in medical probes promises unique capabilities for clinical diagnostics.
28 December 2008
A new diode-pumped solid-state laser offers the technology to complete the triad of red, green, and blue sources needed to produce full-color images.
24 December 2008
Microfabrication and assembly techniques can build high performance miniature microscopes for clinical diagnostics.
22 December 2008
Tools employing low-energy radiation are being developed for clinical applications where knowing the full extent of disease is vital.
16 December 2008
Semiconductor devices based on high-electron-mobility transistors can be functionalized for specific applications.
16 December 2008
Computed tomography colonography employing partial volume image segmentation improves detection of the colonic mucosa layer and thus of potentially cancerous polyps.
15 December 2008
Ablating a biological sample leads to atomization of a small amount of material in a hot, light-emitting plasma that can then be effectively analyzed.
15 December 2008
A near-IR-based portable device can identify and localize suspected brain bleeding in trauma patients.
15 December 2008
Integration of highly sensitive photonic biosensors and microfluidic technologies provide new possibilities for molecular diagnostics.
3 December 2008
A model that captures how people view a multilayer 3D terrain may lead to better visualization schemes.
1 December 2008
Combining broadband near infrared spectroscopy and magnetic resonance imaging of breast tissue allows more accurate quantification of the constituents in suspected tumors.
1 December 2008
Quantum-dot nanoprobes enable real-time quantitative noninvasive assessment of epidermal growth-factor receptor in animals transplanted with human cancer cells.
24 November 2008
By raising the temperature in tumors, optically activated nanoparticles can make existing treatment more powerful.
17 November 2008
A physical model of image formation combined with a reconstruction algorithm results in superior optical projection tomography reconstructions.
6 November 2008
Computational approaches to optoacoustic tomography allow optimization of imaging systems for biomedical applications and efficiency testing of image-reconstruction algorithms.
5 November 2008
Advances in background-noise reduction lead to ultrasensitive protein and DNA sensors for detecting oral cancer.
22 October 2008
Observing surface-texture evolution of nanocrystalline films in situ using reflection high-energy electron diffraction aids in creating novel nanostructures.
20 October 2008
Nanoparticles doped with lanthanides such as holmium and thulium possess useful optical properties for a range of applications including computer displays, lasers, and bioimaging.
15 October 2008
Feedback control systems combine models and experimental data to guide thermal treatments of tumors.
6 October 2008
A new fiber-based probe may enable surgeons to simultaneously view and eliminate individual cells.
6 October 2008
Combining light and ultrasound in a single hybrid technology enables multiscale, high-resolution imaging deep into biological tissue.
22 September 2008
Quality of life studies after laser eye surgery complications may provide impetus to further improve technology.
5 September 2008
First principles in quantum mechanics reveal nature's upper boundary concerning the speed and efficiency of optical technologies, with practical consequences for electro-optics devices and applications.
29 August 2008
Extract, quantify, and interpret intrinsic tissue polarimetry characteristics using a novel Mueller matrix decomposition approach.
29 August 2008
Minimally invasive microsystems employing flexible, thin, compliant substrates and optical or electrochemical detection methods can monitor a wide variety of biomolecules just under the skin surface.
20 August 2008
A new 3D computational approach constructs realistic optical phase contrast microscope images of gold nanoparticles in biological cells.
19 August 2008
New two-photon–activated porphyrin designs allow specific, noninvasive targeting of subcutaneous tumors several centimeters below the skin surface.
14 August 2008
Adding a special lens between an object and a conventional optical microscope can improve image resolution to below the diffraction limit at visible wavelengths.
1 August 2008
New magnetic resonance imaging processing tools allow white-matter fiber bundles to be segmented and tracked in regions of high complexity.
30 July 2008
The detonation of silica-gold nanoshells at energy levels safe for normal tissues and their unprecedented low threshold for vapor bubble formation in solution highlight an advance in cell-killing nanotechnology.
11 July 2008
The in vivo study of the melanin absorption spectrum offers promises of characterizing melanin and associated pathological conditions in their native environment.
8 July 2008
Decay profiles of the local fluorophore environment can provide new opportunities to study biological tissue and cell signaling.
7 July 2008
Advanced imaging near the surface of tissues could assist the development of novel therapeutic agents, drug delivery systems, and diagnostic tests.
20 June 2008
A new approach to automatically identify individuals offers a high level of security while reducing the noise.
17 June 2008
A novel approach to noninvasive assessment of suspicious lesions promises better results with potential for immediate clinical application to tumor diagnosis.
11 June 2008
A project based on biophysics aims to improve the diagnosis, planning, and treatment of cardiovascular disease.
1 June 2008
High-resolution imaging and guidance using optical coherence tomography (OCT) can transfer diagnostic capabilities from the pathology lab to the operating room, enabling real-time tissue visualization and point-of-care decisions.
31 May 2008
The new class of contrast enhancement agents can be precisely tuned to aid in vivo photoacoustic tomography.
12 May 2008
A gray-scale mask for x-ray lithography, made using microelectromechanical systems technology, offers a new approach to manufacturing needle arrays.
5 May 2008

David A. Benaron, CEO of Spectros, has enjoyed a successful career as a physician, researcher, inventor, innovator, and serial entrepreneur by staying focused on the market.

5 May 2008
Polychromatic light-emitting diodes that incorporate 3D faceted microstructures provide good control of color, including pure white emission, without depending on phosphors.
29 April 2008
A device that combines an avalanche-mode amorphous selenium photoconductor with a field-emitter-array readout could provide high-resolution x-ray images at low doses.
29 April 2008
Increased temporal sampling rates make it feasible to quantify lung perfusion using 4D computed tomography.
15 April 2008
Hyperspectral methods using acousto-optic and digital micromirror devices have the potential to improve imaging speed and accuracy with an expanding range of uses, including clinical diagnostics.
15 April 2008
A high-power fiber-based spontaneous emission light source with a tunable filter can be ideal for Fourier-domain optical coherence tomography systems used in biomedical applications.
10 April 2008
Microchambers in photostructurable glass enable the dynamic observation of aquatic microorganisms.
7 April 2008
Wavelength-selectable high-peak-power picosecond optical pulses yield more detailed imaging of biological tissues.
30 March 2008
An assessment method that incorporates focal-spot blurring and scattered radiation optimizes the performance of a fluoroscopic detector.
27 March 2008
Innovative applications include terahertz pulsed spectroscopy for solid-state analysis and terahertz pulsed imaging for tablet coating analysis.
25 March 2008
Using a 4D computed tomography technique, it is possible to trace a tumor's 3D trajectories during a breathing cycle, increasing the probability of a successful treatment.
21 March 2008
In 3D ultrasound images, the ribs can be used as the pivotal reference point for defining the breast region.
13 March 2008
Quantifying placental calcification and infarction aids the obstetrician in assessing these well-established indicators of potential complications.
5 March 2008
Preliminary results from an automated system for analyzing breast lesions suggest that it performs comparably to a breast radiologist.
5 March 2008
Biomolecular motors enable active transport in biology, potentially making possible active materials capable of rearranging their components, or even molecular conveyor belts and forklifts for manufacturing at the nanoscale.
27 February 2008

A low-noise silicon hard x-ray imaging device promises improvement over conventional technologies for future astronomical missions and medical applications.

26 February 2008
Optical approaches provide robust and relatively non-invasive methods for excitation and detection of the motion of micro- and nanomechanical structures.
25 February 2008
The implementation of a JPEG2000 Interactive Protocol–based communication system allows rapid access to high-resolution medical images from low-power handheld devices.
25 February 2008
Near-IR light treatment modifies cellular function, promotes cell survival, and improves outcomes in laboratory and mouse models of Parkinson's disease.
24 February 2008
Micro x-ray imaging tracks nutrients pumped though porous synthetic tissue scaffolds by rhythmic squeezing.
22 February 2008
A stationary tomosynthesis mammography system with a carbon nanotube-based x-ray source array can shorten imaging time and improve image quality.
20 February 2008
Linking changes in arterial microstructure with fluid dynamics of blood flow provides a detailed account of how aneurysms develop.
15 February 2008
A computer-aided detection system uses sagittal proton-density-weighted magnetic resonance images to detect meniscal tears in the knee.
13 February 2008
Novel swept light sources find applications in optical coherence tomography imaging systems.
5 February 2008
A digital holographic technique has an extended measurement range and improved resolution at infrared wavelengths.
4 February 2008
Femtosecond pulse technology can isolate and penetrate embryonic cells for delivery of nanoparticles and DNA.
28 January 2008
Longer wavelengths from a tunable laser improve performance for angioplasty, lithotripsy, and mass spectrometric protein analysis.
26 January 2008
High-sensitivity compact gas-sensing devices may soon replace current bulky detectors used in industry and medicine.
10 January 2008
A large surface area with easily modified chemistry makes porous silicon an effective transducer for optical biosensing.
10 January 2008
Focus engineering of coherent anti-Stokes Raman-scattering microscopy enhances biomedical imaging capabilities.
9 January 2008
A new technique for targeting viral capsids may be applicable to a wide variety of pathogens.
21 December 2007
Extremely thin, flat plasma lamps can illuminate broad areas and have potential applications in medicine and other fields.
19 December 2007
Using a common chemical reaction to produce an easily detected gas simplifies the measurement of breath acetone for medical diagnostics.
6 December 2007
A low-cost, noninvasive means of imaging red blood cells shows promise in applications aimed at assessing tissue viability.
2 December 2007
Microsystem technology is an emerging approach to flow cytometric blood cell analysis based on impedance, fluorescence and light scattering measurements.
19 November 2007
Throwaway devices may be the key to bringing high-performance sensors to market for use in medical applications.
6 November 2007
With minor system modifications and the addition of a high-repetition-rate laser, a commercially-available ultrasound imager can produce optoacoustic images for medical applications.
6 November 2007
The new operating rooms of Varese Town Hospital incorporate a computerized image acquisition and distribution system that can be used in medical education.
25 October 2007
The spatial conformation of surface-bound biomolecules is clarified using a new sensor that could prove useful in biomedicine.
25 October 2007
Ultrasound-induced modulation permits the collection of fluorescence images from deep within light-scattering media.
3 October 2007
The use of digital optics to compensate for aberrations simplifies the digital holographic microscope while increasing the accuracy and resolution of full-field phase measurements.
3 October 2007
Two-photon fluorescence microscopy can be used for non-invasive skin cancer diagnostics and topical drug delivery investigations.
30 September 2007

Early diagnosis increases the likelihood of effective cancer treatment. Nanotechnology offers several ways to improve patient outcomes.

14 September 2007
A wireless address event representation protocol could find use as a low-power, asynchronous system to record neural activity and act as an interface between prosthetic devices and the brain.
10 September 2007
Combining Raman spectroscopy with chemometric analysis allows the rapid identification of single microbial cells without the need for time-consuming microbiological cultivation methods.
5 September 2007
Microdialysis may offer advantages over current methods of performing essential blood measurements by sampling intracellular fluid with a catheter placed beneath fatty tissue.
27 August 2007
Mass spectrometry can be used to identify the biomolecular species present in laser-ablated material from bone and teeth.
23 August 2007

Harold Szu discusses wellness engineering and how technology developed for the military can help monitor diseases such as diabetes.

16 August 2007
A fast-response integrated opto-chemical sensor system can detect ultra-low concentrations of ammonia with high reproducibility.
8 August 2007
Total-internal-reflection fluorescence can be exploited to study real-time biomolecular binding processes with enhanced signal-to-noise ratio.
1 August 2007
The imaging of axonal fibers and connectivity in the human brain are improved by grouping anatomically similar fibers.
31 July 2007
Eye aberration measurements can be used in wavefront-guided laser ablation and clinical research applications.
25 July 2007
Create personalized computer eye models to simulate an individual's vision quality using optical and mechanical engineering software.
17 July 2007
Offering possible advances in everything from computing to spectroscopy, plasmonics represents a powerful technology.
16 July 2007
Nanometer-sized gold particles interacting with electromagnetic fields, fluids, and biological objects can be visualized using a specialized imaging technique combined with dark field microscopy.
4 July 2007
By providing an integrated approach to alleviate the current fragmentation of relevant information, a novel data management system will have a major impact on the treatment of cerebral aneurisms.
26 June 2007
Rats with genetically encoded color probes such as green and red fluorescent protein have been developed for specific biomedical research applications.
21 June 2007
A 3D extension of the standard will support cuboid volumetric data sets with no time component.
19 June 2007
A new approach in optical architecture promises small-scale, high-resolution in vivo imaging for medical applications.
29 May 2007
A microdevice equipped with polarizing filters and an organic photodiode enables detection of dye concentrations in the low nanomolar range.
23 May 2007
A variety of alternative approaches to 3D microscopic imaging can overcome various shortcomings and expand the range of areas and applications.
13 May 2007
Digital off-axis holography with coherence-domain depth gating can measure subcellular motion inside tumors that respond to anticancer drugs affecting the cytoskeleton.
13 May 2007
A smart microfluidic control system that is capable of monitoring clinically-relevant parameters can sample, dispense, and deliver biological fluids to a sensing unit.
10 May 2007
Theodore Maiman, who died in May 2007, is known for creating the first working laser out of a discredited material -- ruby -- in May 1960.
9 May 2007
The two-photon-polymerization process may be used to create medical devices such as middle ear prostheses that are specific to individual patients.
4 May 2007
Automatic search and retrieval methods applied to a large brain dataset can extract valuable additional information.
4 May 2007
Incorporating gold nanoparticles into viral protein provides a tool for studying viruses.
5 April 2007
High-resolution optical coherence tomography serves both as a noninvasive observation method and a therapeutic tool in chronic skin diseases such as scleroderma.
3 April 2007
Anisotropic surface roughness enhances the bending response of ionic polymer-metal composite artificial muscles.
30 March 2007
The noted researcher in biomedical optics discusses new imaging techniques involving nanotechnology, plasmonics, and the use of molecular sentinels for biosensing and diagnostics.
27 March 2007
An improved technique for selecting and immobilizing biomolecules in microstructures promises more-effective patterning of proteins and cells for microtechnology applications.
22 March 2007
Combining spectroscopy and imaging with computational pattern recognition may provide a fast, non-invasive way to detect and diagnose diseases near the body surface.
22 March 2007
A laser-based technique can monitor sap flow in trees, solving a long-standing problem in plant biology with additional implications for climate change modeling.
20 March 2007
Laser gas analyzers are an efficient way to study variations in gas-exchange processes between vegetation and the atmosphere under anthropogenic stress.
20 March 2007
Laser-induced explosion of absorbing nanoparticles, so-called nanobombs, can kill cancerous cells.
20 March 2007
Double-clad photonic crystal fibers and microelectromechanical mirrors significantly improve the sensitivity and miniaturization of nonlinear optical endoscopes.
20 March 2007
A laser-based technique can monitor sap flow in trees, solving a long-standing problem in plant biology with additional implications for climate change modeling.
20 March 2007
A low-cost retro stereoscope for virtual reality and other immersive applications uses flat-panel LCDs and achieves high field-of-view with high resolution.
20 March 2007
Birefringence and transparency of selected liquid crystals at terahertz (THz) frequencies promise added functionalities for liquid-crystal-based THz photonic elements such as phase shifters and filters.
20 March 2007
This month's featured patent review by analysts from Nerac
12 March 2007
RF-controlled battery-less microvalves are fabricated on a biocompatible substrate that allows for communication and remote actuation.
5 March 2007
New photodynamic cancer therapies combine the tumor detection and imaging capabilities of nanoparticles with the increased penetration depth of infrared two-photon excitation.
27 February 2007
Lateral shear interferometry combined with digital holographic microscopy can provide quantitative optical phase measurements with the use of a new, single image, reconstruction procedure.
20 February 2007
Varying pH makes it possible to control conformational changes of polymer chains attached to stimuli-responsive interfaces.
19 February 2007
The light-scattering signatures of bacterial colonies, which depend on minute genetic differences, may provide a way to rapidly identify pathogens in the food supply.
16 February 2007
As temperature changes, the change in backscattered ultrasonic energy is nearly monotonic, thus potentially enabling noninvasive 3D temperature imaging.
12 February 2007
In this video of his Photonics West presentation, David Krohn shares expert advice and perspective on the market potential, technology, opportunities and barriers in biophotonics.
5 February 2007
Polymer layers for microarrays patterned by laser ablation adsorb biomolecules only in specified regions and improve solid-phase transfection of cells when a voltage is applied.
5 February 2007
Optical interferometry reveals tiny motions in live cells that convey information about membrane properties and disease.
4 February 2007
Combining time-resolved photon counting, scanning optical techniques, and atomic force microscopy provides new tools for single-molecule investigations.
30 January 2007
Infrared spectroscopy combined with statistical analysis can identify and discriminate among vegetative bacteria, bacterial spores, and background interferents.
29 January 2007
A novel band selection technique developed for feature extraction of hyperspectral images uses a heuristic optimization algorithm.
29 January 2007
A thin-walled glass microfluidic channel can incorporate multiple optical ring resonators around the capillary diameter to act as sensors on a high-throughput lab-on-a-chip platform.
25 January 2007
Combining a deformable mirror with a super-resolution algorithm enables higher-resolution images from a relatively simple system.
22 January 2007
A new viewer can form enhanced pictures of objects in the dark, without the use of a camera or display.
18 January 2007
Thermal lens microscopes and microchemical chips aid in miniaturizing functional chemical laboratories.
18 January 2007
The high circulating intensities in ultrahigh-Q optical microresonator sensors improve their sensitivity enough to detect a part per million of heavy water in water.
8 January 2007
Technology developments have enabled the deployment of hyperspectral sensors to new application areas.
4 January 2007
An antibiotic can mitigate low-intensity microwave damage to red blood cells by reorganizing the structure of water.
13 December 2006
Fluorescence spectroscopy combined with new diagnostic algorithms can be used to differentiate between early-stage benign and malignant skin lesions.
13 December 2006
A new technique for performing minimally invasive surgery inside the beating heart provides a visual representation of the surgical environment.
13 December 2006
Femtosecond excitation around 1μm offers prolonged, in vivo imaging of biological structures using nonlinear multimodal and fluorescence-lifetime imaging microscopy.
13 December 2006
Microscale approaches to depositing liquids on surfaces are suitable both for making biomolecule microarrays and as tools for rapid prototyping.
12 December 2006
Three-dimensional imaging and simultaneous time-lapsed tracking of many objects is now possible in environments such as the deep ocean.
12 December 2006
Both light scattering and fluorescence of membrane glycoproteins can be used to detect programmed cell death (apoptosis) quickly and cheaply.
29 November 2006
Direct laser ablation produces waveguides, micro-channels, and optical circuits in a single processing step, which could drastically reduce manufacturing costs.
29 November 2006
The latest featured patent review by analysts from Nerac examines new developments in laser eye surgery.
29 November 2006
A novel bioelectronic sensing device offers several potential advantages, including mechanical flexibility, and reduction in weight, power consumption, complexity, and fabrication cost.
20 November 2006
A new optical microscope that uses computed tomography and a novel transformation algorithm can provide pathological information about specimens, and distinguish healthy from cancerous tissues.
8 November 2006
Life scientists can capture the internal structure of samples with high resolution and minimal damage using adaptive-optics techniques borrowed from astronomy.
5 November 2006
Silicone materials and broadband optical interrogation dramatically improve the sensitivity of small interferometric fiber pressure sensors of relevance to biomedicine.
5 November 2006
Substrates for sensitive surface-enhanced Raman spectroscopy are made from nanorod arrays prepared by oblique angle deposition.
1 November 2006
A hierarchical detection algorithm quickly finds and isolates critical regions in low-quality imagery.
31 November 2006
The interference of two nonlinear optical signals generated in series can improve image quality in coherent anti-Stokes Raman scattering microscopy.
26 October 2006
Real-time detection of nanoparticles and cells, including cancer, is now possible in blood and lymph flow.
23 October 2006
Ultrashort laser pulses can be used to produce lesions in single blood vessels located in the cortex of live rats, thus enabling the study of microstrokes.
19 October 2006
A low-cost computer-aided system could screen for early signs of diabetic retinopathy, a treatable disease that is the leading cause of blindness in working-age adults in the industrialized world.
18 October 2006
Confocal microscopy in combination with higher-order laser modes can detect and distinguish individual metallic nanoparticles from a single scattering image.
16 October 2006
Activating drugs with light could be better used to fight disease by first simulating the optical properties of the light source and the body tissues being treated.
10 October 2006
Exposing polymers to UV could ease fabrication of cell-coated medical implants and cell micro-arrays for high-throughput screening.
9 October 2006
A freely available software platform can help researchers rapidly and safely prototype systems for surgical applications.
6 October 2006
Display characteristics vary with the kind of monitor under inspection and the method of testing.
4 October 2006
High-speed addressable optical elements enable fast recording of rapidly-changing cellular signals in light-scattering biological tissue.
25 September 2006
An integrated module based on nematic liquid crystal technology has an accuracy better than 1%.
19 September 2006
Florida State University is adapting educational websites it has built to cover the increasing application of optical microscopy in the biological and materials sciences.
13 September 2006
Radiologists can generate better reports by using interactive visualization tools, thereby improving physician efficiency and efficacy in diagnosing pathologies.
10 September 2006
Digital-holographic microscopy can measure the refractive index and thickness of human pancreatic tumor cells and can be used to analyze their morphology.
6 September 2006
A 3D optical imaging system may provide a fast and non-destructive technique to visualize and identify living specimens.
5 September 2006
A visual fixation monitor employs four spots of linearly polarized light impinging on different parts of the bow-tie pattern of polarization states reflected from the eye.
31 September 2006
A low-cost, safe, and easy-to-use imaging system lets a surgeon see surgical anatomy and invisible fluorescence: this both simultaneously and in real time.
17 August 2006
A dual-color fluorescent microscopy system captures the behavior, in real time, of cancer cells as they grow and spread in live mice.
16 August 2006
A combination of experiments and computational modeling show how ultrafast laser pulses are able to bore into glass without heat-related damage.
10 August 2006
Thermal energy intensities generated by surface-plasmon resonance can probe the behavior of molecular structures one flexible bio-molecule at a time.
9 August 2006
New diode-pumped solid-state lasers doped with thulium can be wavelength-tuned around the local water absorption peak at 1.94μm, making them attractive as versatile laser scalpels.
9 August 2006
A novel system using a 3D handheld navigation device allows users to explore volumetric imaging data.
1 August 2006
Ambient light and display luminance contribute significantly to diagnostic viewing conditions in the digital radiology reading room.
12 July 2006
A novel system for imaging electrical activity in the heart can aid in diagnosis, therapy, and development of new treatment strategies.
10 July 2006
New reagents and techniques in cell biology make it possible to visualize cell-signaling mechanisms in real time.
9 July 2006
Wireless tracking technology integrated with facial biometrics can improve security in health care facilities.
6 July 2006
The viewing angle of a 3D display based on integral imaging can be increased by adding a flat holographic array that acts as a virtual lens.
19 June 2006
In rooms for on-screen viewing of medical images, LCD monitors used with brighter ambient lighting can reduce eye strain without compromising image contrast.
19 June 2006
The dispersive properties of photonic crystals can be used to fabricate compact devices with a wide range of potential applications.
6 June 2006
Pulsed infrared laser light provides a new method for nerve stimulation with unmatched precision, and could soon be used in medical procedures.
25 May 2006
A new Raman system, consisting of optic fiber bundles coupled to an axial Raman spectrometer, shows potential for skin cancer detection.
15 May 2006
Detecting specific drug penetration in biotissue may be feasible in vivo without tissue destruction or conventional lab sample analysis.
5 May 2006
A hand-held scanning probe permits easy, rapid, real-time functional and morphologic imaging of cellular and subcellular structures inside living specimens.
1 May 2006
A real-time 3D laser-manipulation system can be used to assemble, organize, and actuate particles, microtools, and living cells.
1 May 2006
A prototype chemical device can perform micro-stirring, pH measurement and control, and even the sensing of single molecules.
1 May 2006
Nanochannels with diameters from 15nm to 100nm were fabricated and used to isolate the fluorescence signal from a single molecule.
27 April 2006
Recent developments in source and sensor technology are leading to new scientific and commercial applications for terahertz radiation.
27 April 2006
The liquid/solid interface provides an ideal environment to investigate self-assembly phenomena and to probe the structure and properties of monolayers at the nanoscale.
26 April 2006
Large, high-performance transducer arrays for medical diagnostics and therapeutic applications can now be realized using CMUTs
20 April 2006
Reconstruction and manipulation of amplitude and phase of the optical field in virtual numerical space generates unique microscopic images
20 April 2006
Electrically conducting plastics and nanoparticles aid simultaneous measurement of the activity of many genes.
19 April 2006
Laser-induced photothermal effects on individual living cells have both diagnostic and therapeutic applications.
17 April 2006
Splitting a model of the colon into two halves and having a virtual camera 'fly over' each one helps the physician detect colon polyps.
17 April 2006
The development of optical multiarray biochips is essential for the immediate rapid screening of patients.
17 April 2006
A new platform of photoluminescent sensors excited by an array of OLED pixels is being developed for a broad range of medical, environmental, and industrial applications.
2 April 2006
Developing low-cost broadband semiconductor IR sources that could enhance the performance and resolution of OCT systems.
1 April 2006
A technique that allows soft x-rays to be focused using reflective elements that mimic a lobster's eye is extended to hard x-rays.
21 March 2006
A new approach based on multi-element source-detector arrays enhances the spatial resolution and depth-discrimination capability of diffuse optical imaging.
13 March 2006
Field-programmable gate arrays (FPGAs) can implement high-performance coprocessors that accelerate volumetric pattern matching by 100-1000 times as compared to PCs.
6 March 2006
A fiber-based femtosecond laser takes advantage of photonic-crystal fiber technology to extend the tuning range to more than 200nm, making it a potential source for biomedical imaging.
3 March 2006
By applying near-infrared en-face OCT to paintings, we can examine the optical properties of the varnish and paint layers, drying processes, and the underdrawings.
7 February 2006

A practical upgrade path from conventional film-screen to digital mammography uses tiled complementary CMOS imagers.

7 February 2006

An array of laser diodes and semiconductor amplifiers should be able to physically model the operation of the brain.

7 February 2006

Laser Doppler imaging (LDI), used for measuring in-vivo blood flow in biological tissues such as skin or brain tissue, has dramatically improved by exploiting high-speed CMOS image sensor technology.

7 February 2006
A new microchip analyzes thousands of cells per minute in an enclosed microfluidic environment.
7 February 2006
New fiber-optic sensor systems enable non-destructive plant biotechnology monitoring.
1 February 2006
From oemagazine October, 2005
30 October 2005
From oemagazine June/July 2005
31 May 2005
From oemagazine June/July 2005
31 May 2005
From oemagazine May 2005
30 May 2005
From oemagazine May 2005
30 May 2005
From oemagazine April 2005
31 April 2005
From oemagazine February 2005
31 February 2005
From oemagazine February 2005
31 February 2005
From oemagazine June/July, 2005. astrobiology
31 January 2005
From oemagazine January 2005
31 January 2005
From oemagazine November/December 2004
31 November 2004
From oemagazine September 2004
31 September 2004
From oemagazine August 2004
31 August 2004
From oemagazine July 2004
30 July 2004
From oemagazine June 2004
31 June 2004
From oemagazine February 2004
31 February 2004
From oemagazine January 2004
31 January 2004
From oemagazine January 2004
31 January 2004
From oemagazine January 2004
31 January 2004
From oemagazine November/December 2004
31 January 2004
From oemagazine December 2003
30 December 2003
From oemagazine December 2003
30 December 2003
From oemagazine November 2003
31 November 2003
From oemagazine November 2003
31 November 2003
From oemagazine November 2003
31 November 2003
From oemagazine November 2003
31 November 2003
From oemagazine November 2003
31 November 2003
From oemagazine September 2003
31 September 2003
From oemagazine September 2003
31 September 2003
From oemagazine August 2003
31 August 2003
From oemagazine July 2003
30 July 2003
From oemagazine July 2003
30 July 2003
From oemagazine July 2003
30 July 2003
From oemagazine June 2003
31 June 2003
From oemagazine April 2003
31 April 2003
From oemagazine March 2003
28 March 2003
From oemagazine March 2003
28 March 2003
From oemagazine March 2003
28 March 2003
From oemagazine February 2003
31 February 2003
From oemagazine February 2003
31 February 2003
From oemagazine January 2003
31 January 2003
From oemagazine January 2003
31 January 2003
From oemagazine September 2002
31 September 2002
From oemagazine July 2002
30 July 2002
From oemagazine April 2002
31 April 2002
From oemagazine March 2002
28 March 2002
From oemagazine February 2002
31 February 2002
From oemagazine February 2002
31 February 2002
From oemagazine January 2002
31 January 2002
From oemagazine December 2001
30 December 2001
From oemagazine November 2001
31 November 2001
From oemagazine September 2001
31 September 2001
From oemagazine September 2001
31 September 2001
From oemagazine September 2001
31 September 2001
From oemagazine July 2001
30 July 2001
From oemagazine February 2001
31 February 2001
From OE Reports Number 204 - December 2000
30 December 2000
From OE Reports Number 202 - October 2000
30 October 2000
From OE Reports Number 201 - September 2000
31 September 2000
From OE Reports Number 200 - August 2000
31 August 2000
From OE Reports Number 200 - August 2000
31 August 2000
From OE Reports Number 200 - August 2000
31 August 2000
From OE Reports Number 195 - March 2000
29 March 2000
From OE Reports Number 194 - February 2000
31 February 2000
From OE Reports Number 193 - January 2000
31 January 2000
From OE Reports Number 193 - January 2000
31 January 2000
From OE Reports Number 186 - June 1999
31 June 1999
From OE Reports Number 186 - June 1999
31 June 1999
From OE Reports Number 159 - March 1997
28 March 1997
From OE Reports Number 157 - January 1997
31 January 1997